These are my actual chronograph results and general observations using the 270 SAA in moderate loads. I shot these loads in my Clements custom 7-1/2" SBH Hunter (tight chambers, lapped barrel, .004 B/C gap). Therefore, my velocity is higher than what you would probably get in an unaltered factory gun with the same barrel length. The bullet was cast of Lyman # 2 and LBT lube. Except where otherwise noted below, I used WLP primers.
-- 13.0/HS-6: 1140 FPS with an Extreme Spread of 35 (most accurate, clean brass)
-- 18.5 /2400: 1235 FPS with an Extreme Spread of 81 (fairly accurate, sooty brass)
-- 18.0/2400: Not chronographed, probably somewhere around 1150-1200 FPS (not accurate, sootier brass)
With the 18.5/2400 load, I also did a side-by-side comparison between Winchester WLP and Federal 150 primers. The difference in Average Velocity and Extreme Spread between the 2 primers is negligible. Federals 150s were 13 FPS faster Average Velocity and 9 FPS less Extreme Spread. I haven't shot the Federals off the bench for accuracy, so I don't know if they shoot better than Federals.
This second observation is subjective, but I believe there is slightly less leading with the 18.5/2400 load than 13.0/HS-6. When I drop back to 18.0/2400, leading is noticeably less than either the 18.5 of 2400 or 13.0 of HS-6, but accuracy was poor -- at least on that day at the range.
Around here, a can of 2400 is $20 verus $25 for all Hodgen powders. So with 2400, I use ~ 1/3 more powder but pay 20% less than for a can of HS-6. When I run out of 2400, I will probably go back to HS-6.