If the point of impact is changing, I'd check the scope and mounts before trying to work up a load, and just picking a start load isn't going to guarantee an accurate load unless you get real lucky, I work up in ˝gr increments, 3-shots each, from start data and always find a suitable load somewhere before I reach the max, then fine tune that load by adjusting seating depth if I want to improve it. If you OE has the muzzleloader forend, it may not be as accurate as the centerfire forend, at least mine wasn't.
You can also try shooting it rested under the frame instead of the forend, with the forend off, if it shoots to the same POI and the groups are tighter, the forend needs work. As a last resort, give Mark a call or email and ask for help, see the CS sticky.
Mine shoots the 160gr Accubond with Rl19 very good.
Tim