When I lived in Idaho, I'd load three Speer .457 inch lead balls, separated by a felt Wonder Wad, over a light charge of smokeless powder.
Muzzle velocity was about 900 fps. At 25 yards, all three balls grouped in a three or four inch circle, so dispersion at that range and less was minimal.
Not a good penetrator, but then I lived in an apartment complex. My Marlin 1895 held four such rounds. I never kept a live round in the chamber for two reasons: (1) Safety, so someone couldn't immediately cock and fire it and (2) Psychological effect. If I ever had to use it, the aggressor would hear the rifle's lever being worked.
This makes a nifty defense round. Getting hit in the chest with three .45-caliber lead balls would likely prove fatal: three entry holes for the medics to plug. I don't believe they would penetrate a body, even at short range.
I no longer use this round. I now have a sweet Remington 870 Youth Model in 20 gauge, with the 22-inch barrel, that works well when loaded with No. 3 buckshot.
The .45-70 load is a hoot to plink with at the range, however. It's fun to fire one shot and see three holes appear in the paper!