Possum:
I spend a week each year hunting south of Walterboro in SC. The deer are plentiful but smaller in size than either in KY, MI, IN. (I assume these are the same deer that you refer to as southern deer). The 180 grain SSP at over 1900 ft per sec should do a real number on them. I also use 180 grain Remington HP. They expand more in my .357 Max but at 1900 ft per sec the core will probably separate from the jacket. The 180 SSP should do well for you.