If you are talking about the grip screw bushings they are threaded AND staked in from the back side. Odds are you will end up stripping them all. Brownells has an oversize tap and oversize bushings to replace stripped frame holes. If they are locktited in you can free them up with a cheap pencil torch held right on the base of the bushing and a good hollowground screwdriver. When I replace the bushing I use red locktite and let it cure overnight. grip screws can be held in place real well by using real small "O" rings under them, been doing that for years and never had one come loose again since I started doing that.
Rebel49