That answer it easy: It depends................
Depends on a lot of things..........Ball powder vs extruded...case capacity vs powder measure capacity, type of powder measure, etc.
As stated in the posts above, some loads have to be trickled to be consistent and some are consistent as long as the loader is consistent. Here are a few things that I do that may help you out:
I always shake my bottle of powder before I pour it into the measure. I don't know if powder at the top or against the sides dries a little or if the powder compacts, or what, but I always get more consistent loads if I shake the powder up a little before putting it in the measure.
After the powder is in the measure, I set the measure and start dumping loads. I do not lock any measure setting until I am within .5 grain under my desired load. Once I am within the half grain of my desired load I lock my adjustments on my measure and check weight again.
If I am using extruded powder, this is my setting. I drop this charge and trickle the last half grain of the charge on the scale to get the exact powder charge.
If I am using a ball powder, I throw three charges and weight each. I then adjust my powder measure up .1 or .2 grains and lock it down. I adjust and lock my measure until it throws three charges in a row that weight exactly the same. Once I have thrown three exact loads, I consider my measure set to load my ammo in this batch.
Depending on the type of powder measure there are little things you can do to make the loads more consistent as you set them up and use them. My Lyman #55 measure is mounted to my bench. It has micrometer type settings on it. It fills the drum when the handle is moved up. It drops the powder then the handle is moved down. On the up stroke, I tap the handle twice, then drop it straight down to dump the powder into the case. Up tap tap down. Up tap tap down. The little taps vibrates the powder down to fill the cavity in the drum. Cavity is more consistently filled each time if you do this. I have a Lyman pistol powder measure with rotors. I can either mount it on the bench, or use it by hand. Same type of stroke, but this measure doesn't have a baffle and doesn't need the second tap. Just one solid up stroke and one solid down stroke. My Dillon measures have the powder bar that slides. As long as I am working my progressive press in rythem, the loads are consitent as the vibration is consistent. Any time I get out of beat, I check my powder charges until my press is loaded and I can get back on beat again.
With flake powders, it is more of a gray area. Some folks will weight the charge. Some will use the measure by volume only. Flake powders are more often used in shotgun shells and in pistols. Some flow consistently thru measures and some don't. Anything I load on a shotgun press is volume period. Once my charge bar is adjusted for appropriate weight, I don't weight again unless I change powder lots or loads. Same with my pistols that are using a flake powder. I pick the appropriate rotor that throws the weight nearest to what I want and then just load up my shells by volume. Shotguns and pistols have more variables in the way they shoot and the powders they use just adds another variable.
I hope I have given you some things to think about. If you have a more specific question, please let us know.
Steve