Sorry for second post, the post function acted up.
The most amazing thing is that the lowest load produces the least wind drift!
I aplied this thinking to a ballistic calculator on the web and was surprised at the little difference an extra 600 fps makes after 50 yards. The wind drift results floored me. I've never studied ballistics much except for the simplistic velocity/energy charts from ammo lists. I always thought faster would be less drift for the same bullet. Turns out drift is related to the rate at which a bullet sheds velocity.
This does not address terminal performance for hunting. Here I had to go anecdotal. Many experienced shooters report good killing power and penetration from round balls to 100 yards. I have no personal knowledge. I do know that my .444 Marlin is a better large animal killer than a 7mm magnum to 200 yards. I've shot enough moose with both to know. Big heavy projectiles kill differently than the high speed small caliber stuff. But they perform way out of scale for what thier energy figures suggest.
The last unknown for my research is the effect of the passing from sonic to subsonic velocities. Target shooters want thier bullets to stay in either range from muzzle to target. What do round balls do when they drop from sonic to subsonic?