300 grain cast bullets over 13 grains of unique is a wonderful place to start. 25 grains of 2400 is also a good starting load. I do not or use fillers or wads with those loads, they are accurate and always go boom. I also have a 210 grain lyman 45-70 mould that makes nice bullets that are about half again as heavy as a round ball and they shoot well over unique also. 45-70s shooting 300 grain bullets is very similar to the old 45-90 load that used only 300 grainers.
best of luck,
regards,
Graycg