I guess I shot a couple deer with the 45-70, and I don't think it wrecked them any worse than a .270 Win.. About the same as a .348, I guess. Less than an 8mm mauser handloaded.
The core-lokt is hell on northern Wisconsin deer. Never found anything better. Having said that, the Noslers, Hornadys, Winchesters, Barnes, and Sierras worked pretty good too.