New to Muzzleloading

[Kentucky Shooter]

I am new to muzzleoading and have a new TC Omega Z5 in 50 cal. I started loading the 223 grain powerbelt bullets and my question is, would you expect me to see a great deal of difference in point of impact if I switched to the 245 or 250 grainers in the same brand bullet? I sighted it in for the 223 grain bullets, but found a value pack (significantly cheaper) of the heavier bullets and wondered how much these might change my point of impact at 100 yards. I am using 2 pellets (100grains) of triple-seven.  Thanks for any advice you can offer.

[Buckskins & Black Powder]

very little difference.

[montveil]

Try http://hodgdon.com  and http://powerbeltbullets.com

they have tables that will answer your questions 
I find that using 2 X 50 grains triple Seven pellets with 295 Powerbelts will give you approximately the same impact point at 50 yards as 245  grain Powerbelts and 80 grains (1X30 plus 1X50 pellet) in my 50 cal
I prefer the heavier bullets for deer while the 245 for coyote..The charts show little difference in impact point between the 245 and 223 at 100 yards
If you just want to practice any bullet with 80 grains of Triple Seven pellets will usually suffice as shot groups are what you are looking for and not point of impact. You still will have to zero with the hunting load you will be using.
Loose powder will be less expensive and more versatile but I find the pellets make it simpler for a new ML shooter.
You will have to fiddle with different bullets weights and loads to find what your rifle likes.
Develop a rhythm in your loading sequence until it becomes automatic which will help if you need a second shot for the other deer

[Kentucky Shooter]

Thanks to both of you who posted a comment------I think I will just change to the 245 grain powerbelts. If I have to make any changes to my sights, surely they will be minor.

[DennyRoark]

Sometimes you can make minor POI changes with a tweak of powder charge, say 5 or 10 grains.  180gr XTP/80gr PYRO will shoot to same POI as 200gr Shockwave/90gr PYRO @ 100 yds in my Disc Xtreme.