I'm glad you asked.
If you'll notice, I don't sell many lightweight handgun bullets, but lean toward heavy ones. So very light bullets haven't been considered much in my formula. Yet, the efficiency of large flat noses is so high that bullet weight has little influence on the DV formula if large bones aren't hit. For deer sized game and smaller, which is all most US hunters will ever be able to afford to hunt, the lower end bullet weights which I offer in magnum revolver calibers will hold their wound size all the way through in most cases.
For example the 41 cal weights you name. At the same impact velocity you would not be able to see a trace of difference in the wounds on broad side and quartering shots. On a very large deer hit stem to stern, the wound would be slightly smaller at exit with the lighter than with the heavier, but the deer would go down in it's tracks with either. In fact we can take the weight for 41 down to 180 gr before the performance difference gets real noticable. So, I've kept the formula simple, because that's good enough.
You are definately right that heavier bullets are most accurate, so long as weight doesn't get so extreme that stability from inadaquate velocity/rifling spin, becomes a problem.
Your next and un asked question, Would the WFN penetrate far less than the LFN? Very little. Ross Seyfried told me he shot both nose styles, in either 44 or 45 caliber, I forgot which, at the same speed with the same bullet weights, into wet newspapers. The LFN penetrated 2 inches less, both going something over 50 inches, as I recall, and both holes dead straight right up to where the bullets stopped. Yet the WFN wounds nearly twice as large as the LFN in 44 caliber! We are talking about efficiency that I don't understand, nor does anyone else, methinks.