I've used it in my 480. With medium to lighter weight bullets ie 400 grs and under, it is equal or better than 110/296. With heavy bullets, it is too fast burning.
Lil gun is faster than 110/296. Consider it as a tweener between 2400 and 110/296. It has it's place, but it isn't an accross the board replacement for 110/296.
If I were using Lil gun for a 454, I'd use it for 300 gr and under bullets.