Have I tried it? No
Will I tell you what I think anyhow? Yes
A deer shot in the vitals with that cartridge you have listed will die! Seriously though, that weight bullet at that speed will put a world of hurt on any critter in North America!
Calibers and their ammuntion have applications where they perform best, however the caliber and weight bullet you chosen should cover any need for deer from 0-300 yards. Know your gun, know your distance, you'll blow him up!