I made the big mistake a couple of years ago, of not keeping differant loading of same caliber ammo seperate. The wife loads .44 mag for a carbine. Her loads are way too hot for a pistol, and we all know it. She always put her loads in a baggy and marked them with a Sharpie. Over time the writing got rubbed off and one morning I grabbed them to go shooting with my pistol. Got to the range and the first shot I knew something was not right, too much recoil, then hammer would not pull back. Looked at gun, forced the hammer back and found cylinder was split. I was lucky gun held togeather.
Sent gun to Ruger, they were able to straighten the frame and replace the cylender, and return the gun to me, along with a letter. The letter stressed how close I came to losing my head.