The Hodgdon basic manual says 41 grains. Now it does not state weather that is a max or min load.
CAREFULL !
The Hodgdons basic manual
lists ONLY MAX charges,,on the bottom of every page it say's
NEVER Exceedthat is the same as Max charge..starting loads are generally 10% under max
And they list the 50grn Seirra Soft Point,, not the Hornady V-max. All 50grn bullets are NOT the SAME, I know those soft points have a different ogive than the Vmax
41 grns of H380 is 100% capacity of the 22-250 case
Just a word of caution friend, the same given too me by members here, it's best to stick with ALL the info listed in a manual and not mix an match. Good luck, stay safe
An No it don't make a differance what primer Manufacturer you use, AS LONG AS, you use the right primer. If it say's to use large Rifle, use Large Rifle NOT Large Rifle Magnum.
Read what it say's not what you want it to say,,and DO start low and DO watch for pressure signs.