My own choice would be a 4" barreled double action revolver in .357 mag, using 158 grain hollow points (with a wide hollow point).
Why?
Well, first off, the .357 is more than adequate for something the size of a mt. lion. Plenty of power, and plenty of penetration, even with hollow points. To stop a lion quick, I want something that will penetrate to the vitals, yet will be fast enough to cause major upset to a cat's vital organs as it goes through. The .357 is that balance. Make the cat's blood pressure drop to zero by destroying major vessels and it's going to stop, quick!
Why the hollow point? Cats are thin skinned so you don't need a deep penetrating bullet. Hollow points at a fast velocity will upset more tissue than a cast or soft point bullet. I'm not looking for a blood trail, I'm looking to stop a big cat from chewing me up. Who cares is it exits? I want damage inside, not an exit hole.
A 4" double action revolver is easy to carry, easy to shoot, and quick to get into action. In .357 mag, the recoil is light enough that it's easy to shoot fast in double action mode, too. The .357 is more that adequate for stopping a lion, and it's cheap to shoot so you can get lots of practice.
What else would you need?