I hunt with both scoped and open sights, without a doubt a scope will help with your 40 to 50 yard shots. However it is a different ball game too. The revolver will be heaver , ya may find it harder to find your quarry in the scope....you'll find how much ya really shake. Unless you hunt from a blind with a "built-in rest", ya need to learn to take advantage of all natural rests , trees , stumps , limbs etc.
My Bisley hunter wears a 2X Leo , I still limit myself to around 50 yards....from sandbags it will certainly do its job at much longer ranges. But I'm just not comfortable with the longer shots. With my open sights , 25 to 30 yards is my goal. I figure the same as a bow hunting.
No doubt a revolver was not originally designed to wear a scope....however technology has come a long way, bet the native americans never thought a bow would have pulleys either. Good luck with your decision
regards, irold