For different game I use different bullets and loads...for years the favorite powder for this caliber with my friends and I was IMR 4350. My old .300 is on its 3rd barrel...and 4350 was used most of the time....
1.For very light game deer/antelope/sheep in open country I liked a near max. load of 4350 and a 150 grain Nosler BTBT or Serria Flat base...With this load I have taken mulies, antelope, sheep, elk and black bear...it is a bit light a destroys meat if not well placed but it shoots FLAT....
2.Another excellent load for light game was the Serria 165 HPBT...I used it with a top load of IMR4350, but in the newest barrel switched to Re 22 and a near max. load...Re22 has become our new favorite for 165's,180's, and 200's..
3.My favorite heavy game load is Re 22 and a 200 grain Nosler Part...with all loads I used CCI250's...Over the years I tended to shoot either 165's or 200's..I really haven't used the 180's that much...but it would be a good middle of the road weight...I would try either IMR 4350 or Re22 and a Nosler 180 Part.that load would do most things very, very well.....