I am running into some landowner gun restrictions of late, generally slug guns or 22 centerfire rifles. I put together a 22-250 on a Savage long action (origonally wanted a 22 Cheetah) and decided to use the 1 in 14 inch twist as there are several tough bullets available that this twist will stabilize. I notice a lot of talk on the 223 but little on the 22-250. I have killed a few deer with this cartridge using Hornady's 60 gr, soft points and HP's with very good results and am planning to put the Nosler Partition in this cartridge to work.