Most revolver cartridges don't require a huge amount of lube. You will likely find that the chambers of 99% of .45 Colt revolvers are quite generous in their dimensions - enough so that full length sized brass has to expand quite a bit to seal the chamber. I normally only size the portion of the case that actually holds the bullet, simply to minimize the amount the brass is worked. If you do so, accuracy should be slightly better than otherwise, and brass life may be significantly longer. Accuracy frequently improves because the body of the case is centered a bit better in the chamber, so the bullet is better aligned with the bore.