I have been told that the metal formed to make pistol primers is not as thick as the metal used in rifle primers. I have also been told that pistol primers may seat deeper in the primer pocket as opposed to rifle primers, and that this can be a cause of mis-fires. I have never tried to load rifle cartridges using pistol primers so I really don't have any experience with this scenario. That said, since 45/70 is a low pressure cartridge and you are using Trail Boss you might want to load one or two rounds to see if it will work for you. I still think that it is prudent, as HL stated, to stick with the info available in your reloading manual.