The longest shot I have made on a deer was with the 444, 265 yards. I estimate the drop at around 18 inches. It was with a factory load, 240 gr, complete penetration. Doe ran about 40 yards. It was from a late 60's model marlin. It gets about 1.25 " groups @ 100yd. I now have a Handi 444 that I am working with, using only cast bullet loads, just how good it will be remains to be seen, but it took my deer last year @ about 70 yards with the 245 gr cast. I would say that if you know your trajectory it is a 200yard gun with no problems at all, and probably 250.