Your first request is a pretty tall order. Your gun may or may not be capable of printing 1" groups at 50 yards. Most revolvers that are not named Freedom Arms are happy to shoot 1-1.5" groups @ 25 yards, but you are certainly welcome to keep trying. 240gr bullets have been the choice for most uses with a .44 mag, but you should probably try from 180-310gr to see what results you get. Unique and Blue Dot are good powders for mild to mid-range loads.
As for the 10" 7 TCU, 140gr bullets going faster than 1500-1600fps should provide enough power to take over rams. This is probably on the minimum side, but you should try it out as there is no teacher like experience. Some good powders to try here are H322, WW748, H335, H4198, H4895.