My avatar is a 13 inch 460 Mag. I can't say how 460's do in it as I already loaded 45 LC's and 454 Casulls and just didn't see the need for another 45 caliber loading. I figured if a 454 couldn't kill it I needed to break out one of my 500 S&W mags or leave it alone. On accuracy both the 45 LC's, which are loaded hot to TC, Ruger, Freedom Arms specs, and the 454's will easily do a 2 inch group at 100 yards with my wobbly self at the trigger.