The loss of velocity will cause a lessening of the energy delivered and the amount is variable lossly based on the cartridge. The higher the intensity rounds uch as the 22-250 lose more than say a 30-30. Still velocity lost is energy lost. If the remaining energy is sufficient to the task at hand all is well. Also faster powders lose less velocity as the barrel is cut than the same cartridge loaded with a slower powder, although usually the slower powder will generate higher velocities for a cartridge, of course this can vary by load and individual rifle.. Measure what you end up with, used the balisitcs tables to calculate energy at range and concentrate of shooting well. Remember a bullet only works if its put in the right place!