I think that the 50 is the way to go----I have a VXII in a 4x12 on a Speedmaster .22.
The after thought will find me purchaseing a VX3 in a 4.5 X 14 for the T-Bolt Browning .22 that is a projectfor the first of the year, 40mm.
Hard to get a 50mm on a .22 properly.
If I get---yea, I know, snickersnicker--the Bolt, tube fed Marlin with a Bull Barrel I will put a 50 on it.
The thinking for a gun past the T-Bolt may be a .223 for some amount of range---in this case---well in this case, the project could end up with something from the custom shop or at least a long range piece of glass.
Course, all I am doing is punching paper.
Blessings