I'm saying that when i'm in a full-sized, sturdy, permanent, treestand that is built like a kid's treehouse I sit in a chair holding the rifle pointing outboard in my principle direction of fire with the safety off and my finger indexed above the triggerguard, forend of the stock (or bipods) resting on the railing and more or less pointing at where the deer is SUPPOSED to pop-out. if the gun moves from that position, or if I change that hold, then it goes on safe. I don't fidget around in my pockets getting my chew and soda with the gun bouncing around waiting for the trigger to get snagged.
This year I was in a ladder stand, in an area I'm not totally familiar with, high-up and there was the possibility that me and the gun both would have went down and the safety didn't come off in three days.... because when I went to fill my does tags I never saw one long enough to get my crosshairs on it. Also I had a pistol out for close up shots and figured I could bump the rifle around and possibly snag the trigger on my mesh blaze orange vest while leaning over the rifle to take a pistol shot. Also muzzle control was in a safe/wooded/uninhabitied area but not at my principle direction of fire so I kept it on (it was sitting across my lap OR slug on a hook next to me depending on what I was doing, either way the muzzle was lateral or skyward).