Years ago, a gunwriter did an article which really delved into the myriad of problems facing creating the perfect cylinder. It's not just a matter of timing, but of boring true, and concentrically. He was surprised revolvers were as accurate as they really are, and were in the olden days as well. Supposedly, you will get your absolute best accuracy if you were to fire a group from the same chamber. A way of doing this is to place 6 targets up, and with numbered chambers, fire at each one making sure you use the same chamber on the same target each cylinder full. I don't have the patience to see how closely my revolvers can group, when they already group close enough for me.
Dan C