I like the 210 grain Hornady XTP, but you can't get them factory loaded. Fed makes a 250 grain Castcore cartridge, and the Winchester Platinum tips look excellent. My buddy uses the Platinum tip shotgun sabot slugs, and they are AWESOME.
I bought a S&W 657 Classic Hunter II, NIB, a few weeks before the season opened. After a couple trips to the range, I took a nice 8 point buck late in the season. A 30 yard neck shot dropped him where he stood. This is my 4th handgunned deer, and my first wall hanger. 15" inside spread, and TALL tines.