Since you got 7 responses and none addressed your question, here goes:
On rifles like that I fill the hole with mould release agent (I use probed 2000 and it comes with release wax. You could use any other wax compounds like shoe polish if you don't have the real stuff) That allows you to place the action in the stock and the epoxy not get into the hole. When you put the screw in, the wax gets forced around the barrel shank threads and keeps any epoxy from sticking to them so you may remove the barrel in the future. It also keeps any epoxy in the hole to a bare minimum. Any that may be in the hole at the bottom of the screw is easily removed with a pick once it is cured, since everything in the hole is covered in release compound. Also use a toothpick to kind of clear out the epoxy in the stock that will get squeezed into the path of the screw before you put it in, to minimize how much gets forced into the hole. BTW, this is pretty much the only way I have found to do Ruger 77s since you can't have a guide screw in the receiver and get it into the stock at the same time.