IMHO, the 22H shines as a Maxi CF version of the 22WMR; after that I would have gone to a 223 and been good for any distance I have available. The fast twist Hornet doesnt really have the powder capacity to make heavier jacketed bullets do much for you, but for heavier than 45gr. cast bullets with a better BC and, yes, more of a loopy trajectory, and a lot of thwack I could see it work out.
Thing is for me, after 3000+ rounds through 3 different 22H's, mostly cast, I decided that if I wanted to have the option of shooting more of a load then the 223 would do it (and I could always load it down to Hornet ), but I had tired of 22cal. projectiles.
The Hornet requires more delicate case handling too and watch out for streach. I used the Lee Case Length Gauge after every firing of HV loads since it is just so easy to use and keep brass consistent, then the Lee Collet Neck Size Die tuned to 'my' perfect fit. Cases really lasted!