Ive tried the Aguila SSS, 60gr in sgl and dbl actions and they loose accuracy at distance due to low velo and understabilization, but for practical handgun, iron sight ranges they carry a lot more thwack and didnt group badly out to 30ish yards or so. They may not shoot to your sights but once you learn the hold its no different that 38Spl in a mag sighted gun.
If I didnt have my 38Spl walk-about I would load up the .22 with 'em.