The Sierra #4 manual gives 49 grs IMR 4350 as the accuracy load with their 117 gr bullets. I have used this load for years to kill over 100 whitetail deer. I use Rem cases, CCI 250 mag primers, and the Pro Hunter flat base bullet. Out of my 26" Shilen #6 SS barreled Rem 700 I get 3000 fps and bug holes at 100 and average 1 3/4" 5 shots at 300 yards. 99.9% of the time deer drop in their tracks with a front shoulder shot.