James,
I use Missouri Cast Bullets in 9/.40/.45, for action pistol games. They are hardness optimized for action pistol velocities. These are used in Glocks, CZs, 1911s, and Hi Powers. The Glocks have aftermarket barrels. I had leading problems in the 9mm Glock, mostly due to a rough bore and driving them a bit fast (1125fps). I fire lapped the barrel and dropped the velocities down to 1050 and pretty much cured the problem. In the .40 I use the 170 LSWC (Bn 18) with very little leading. It's easily removed with minimal cleaning. I also soak the clean bores in CLP, which seems to help prevent leading as well. No problems with leading in .45 in any of my pistols. At the volume I shoot, I save a lot of money loading cast bullets.
Savage