could be very little and could be alot. The actuall differnce in velocity will only change point of impact a inch or two but where things get dicy is that the same gun might shoot one of those loads into an inch at that range and going up or down a grain can open groups up to 3 to 4 inches. Now add the one or two inch differnce because of velocity and you sure could miss the vitals of a game animal. I guess what im saying is the only way your going to really find out is to shoot it.