I would think if the crimp grove was not used the crimp would lead to erratic pressure differences at the bullet release from the case.
When shooting IMHSA I learned a revolver shot most accurate when the cases were the same brand, shot about the same amount of times , the powder same weight by measure and crimp was a profile crimp to the front of the crimp grove . And all cases were trimmed to same length ,reamed and camfered. With crimp being one of the important I never experimented with seating depth unless there were two crimp grooves.