Bill is she a shooter?? If so take her along and let her pick out, be better in the long run.
Whats the main concern, 2 leggers or 4, the Bulldog in 44spl will work for both, but so will the 38spl. Handloading self defense ammo always brings out the hue and cries for and against, but if she likes the 44 I would lean more toward a wadcutter type bullet than a JHP, not sure but you find its hard to locate a 44 slug that will open up at Russian speeds, and a good ole solid wadcutter has settled the has of many a creature.
If she would be more comfortable with a semi I would look at the Berreta models wit the tip up barrel, pop it open down in a round close barrel, and the trigger work is DA/SA as I remember, but I think , but not sure its limited to 380