My tried and true ammo of choice is Remington core-lokt in 130 or 150 grain. It always penetrates through to give you an exit hole and therefore a blood trail, but bullet expansion is good, too. Boiler room destruction is nearly complete on a good hit. A deer hit with a core-lokt will often run, but never more than 100 yards in my experience. Finding them is usually easy with the adequate blood trail. There are a lot of more expensive brands, but core-lokt has never failed me. (I am in no way affiliated with Remington, in case you are wondering)