The throat measurements of .448-.449 has been the norm for every Ruger 45 colt that I've bought and a couple friends have bought over the past 20 years. Thats over 10 total. If you send it back to Ruger they won't do a thing for that issue. Those figures are within their "specs". You should be fine as long as you're shooting jacketed. Lead will be the problem. Lots of info here and other places on lead bullet accuracy and reducing leading. Most all will say "bullet fit is king", I agree. There's a guy called cylindersmith who does cyls for around 30 bucks. Thats a good deal, but if you're going to be doing more than one, then buy a reamer and cyl guides from Brownells or whoever and do it yourself, it's not difficult. Opening the cyls to .452 and possibly firelapping (as I've never seen a Ruger without barrel constriction at the barrel/frame) should make a big difference in both leading issues and accuracy. I've done all my personal Ruger 45's and a couple friends guns. There was improvement in all.