With a 1.5"-high-at-50 sighting, it would still be rising at 100 yards (about 2.5"), and would be zeroed at about 165 yards. However, assuming you are hunting moderate-sized game that would not be impractical and would give you almost 200 yards of range without bothering with holdover.
If you set it 1" high at 50 yards, that should give you a zero of about 140-150 yards depending on specifics like exact sight height and muzzle velocity. It will only rise to a bit over 1.5" by 100 yards. That would probably be the most practical zero for this caliber and your desired use.