First let me congratulate you on a fine gun (once you can get it to shoot!). I don't think you will find a new cylinder pin to be helpful. It sounds like the throats and bore are good also. I once owned one of the early .45 Blackhawks that had thge .454 throats (like Colt) and a .451 barrel. That one wouldn't stay on a barrel at 50 feet until I fed it .454 sized bullets instead of the .452 I had been trying. The next place I would consider is the barrel. Check the rifling, then the forcing cone and see if you have both, and if they look good. I have seen some guns that got through without a forcing cone at all! f the forcing cone looks good, the I would guess then next place to check would be the muzzle and make sure it has no nicks or dents. Take a soft cotton glove and feel if the crown has any burrs also.
If all else fails, you can contact Ruger and send it back. It is definately outside of their acceptable accuracy standards. Good luck with it, 44 Man.