What size of pests to be controlled and at what distance they are shot should be the main reasons when selecting a cartridge to be used. There is not one ideal cartridge for shooting all the different pests- varmints located and hunting conditions in various areas within the United States. That's why people may like different cartridges. I m an old timer and have tried out 17 HM2, 17 HMR, 17 Hornet, 17 Fireball, 17 Remington, 204 Ruger, 22 RF, 22WMR, 22 Hornet, 221 Fireball, 222 Rem, 223 Rem, 22-250 Rem, 220 Swift, 243 Win, and some big game cartridges for shooting pest- varmints. Even the lower power 17, 20, and 22 caliber air rifles that I have are at times are handy to have. At any given distance shot the bullet or pellet must have the energy level to kill the pest-varmint shot. So which 17 cartridge for pest control , could be none ,or it could be any one of them.