I own 357's, 41 mags, and 44 mags, and all will kill deer and bear, as well a heavily loaded 45 LC....love 'em all.
My Redhawk 44 mag was always My hunting weapon of choice for many a hunt, and it filled My tag most of the time.
One opening day, I decided to carry a 41 mag handgun, and although loaded for big game, the 41 cartridge failed to penetrate a small patch of brush which I'm sure My Redhawk would have. Never even touched the largest white tail that I've ever seen.
I never carried any other handgun ('cept My Redhawk 44mag) on a big game hunt again.
Go big and potent, because the ideal situation seldom presents itself.