The answer is, it depends.
Mostly on what the rifle is. If it is a #4 or #6, the only appropriate use is a .22 rimfire or obsolete .32 RF. The #4 can be distinguished by the fact that the breechblock and hammer pivot on thin bolts instead of almost 1/2" diameter pins. You can convert the .32 RF to .22 by welding and redrilling the breech block.
If the rifle is a #2, (distinguished by having a curved surface where the buttstock meets the action) it is suitable for a .22 rf, .32 rf, or small pistol type cartridge loaded lightly. Again, the block can be converted by welding and redrilling.
If the rifle is a #1 1/2, (distinguished by a full size frame with flat slides, no step at receiver ring) It is suitable for small pistol cartridges and some light rifle cartridges in addition to the rimfire.
If the rifle is a #1, it is suitable for most blackpowder era rifle or pistol cartridges, loaded with bp loads or very light smokeless loads.
Best of luck,
dave