NO!!!
If SSK won't chamber for it it is unsafe.
One well know custom gunsmith/porn purveyor chambered one in 460 Weatherby which is the same case size as the 30-378 and had dismal luck with it.
He even stopped chambering for the WSM line of cartridges at the behest of T/C.
Remember if SSK won't chamber for it don't consider it.
It is safe with standard Magnum case head size. Like the 458 Mag/458Lott, 300 win Mag type cases.