I anneal my cases every 2 to 3 firings. Firing and resizing cases will work harden them and after 3 to 4 cycles, the cases will reach maximum hardness. Your ammo will be more accurate with "soft cases" and the cases will last a few more shots. If you wait for splits and cracks to appear, you waited too long. The reason for annealing (shoulder to mouth) is to eliminate splits and cracks and allow the bullet to be released straight with the bore. Usually, annealed cases will give out from primer pocket problems or head separation long before splits show up. I anneal cases, then resize, then run them through the case cleaner. Probably doesnt matter what order but my results are excellent.