I try to limit my 22 LR shooting to animals no larger than jackrabbits. I don't think I would attempt a shot on a coyote or similar sized animal unless I could deliver a head shot. I would probably follow the same advice with a 22 WMR and they have much more steam than even the hyper velocity long rifles. I've had two coyotes escape me after being solidly hit. One was early in my reloading days when I used a match hollow point out of a 222 Remington and the bullet did not expand. The other was a 38 Special +P load with a 158 grn SWC loaded to 950 fps. Both incidents serve as reminders to me that coyotes can take a lot of lead and still make their escape if you're not very quick with a follow up shot... I prize my 22's as much as anything in my firearms collection and have shot countless hundreds of critters with them. Still I've learned one is best served limiting their use to smaller varmint or game animals. In my experience this includes ground squirrels, cottontail rabbits, jackrabbits, sparrows, crows, rattlesnakes, magpies, tree squirrels, and others I can't remember at the moment. You'll enjoy your 22's more if you match the gun to the game. Good luck and good shooting...