yote slayer, i shoot 40 gr v-max molys out of my savage heavy barrel 22-250. They shoot around a half inch at a hundred. I shot 10 yotes this winter with them, from 30 to 350 yds and they were very fur friendly!! Had a couple exits but they were just little chunks of bullet and bone, the largest of the exits might have been as big as a lead pencil. These are runnin about 4150 fps.
I also shoot the 55 gr vm molys in a 223 hvy bbl savage. These shoot one jagged hole at a hundred. I've shot coyotes with these also, they are pretty friendly too if you hit them square, however a little high or low or a tough raking shot they make big holes, it pretty much rips them open!! these are runnin somewhere around 3300 fps. They will also vaporize a prairie poodle!!!!!
the 40's are a little drifty in the wind but i think the speed helps!!
Hope this is useful info, have a great day, 7.21 tomahawk.