I've shot several deer and one black bear with Sierra bullet's. They are accurate and soft. The deer had a lot of distruction inside without hitting any heavy mussle or bone. The bear was hit head on in the chest just under the chin at about 60yds. The bullet never made it inside.
I thing they make great varmit and target bullets but I would never hunt big game with a sierra again. I just don't like my killing to be so messy or unprodictable.