I've also given up on firing .45 Super in the Model 21.
I really like the gun, and am not willing to damage it or to reduce it's useful life.
The recoil with what were lower end .45 Super loads was very sharp, and was strong enough to change the functional dynamics of the pistol. That's when I stop. There are old, bold reloaders, but they often have damaged guns. I choose not to take that chance.
If I feel the need for more punch than the .45 acp offers, I'll use my 629 Classic.